With the promotion of the continuous operational reference station system (CORS) and the development of the Mobile GIS technology, high-precision, fast and accurate GPS vehicle positioning monitoring is important in the construction of the intelligent transportation system. In order to seek for a solution to fast and high-precision moving target spatial location, and improve the application value of GPS location information in vehicle mobile positioning, this article has studied the design and implementation method of the vehicle orientation, monitoring & control system combined with CORS service network and Mobile GIS. It has designed the vehicle positioning monitoring system architecture integrated with CORS and Mobile GIS. It has also analyzed the characteristics of spatial and attribute data related to vehicle positioning control, studied the data classification organization and the integrated model which uses Oracle for object-relational storage of spatial and attribute data, and focused on the space-time cube model of vehicle track data. Besides, this article has made an elaboration on functional design and implementation of the monitor service center, mobile terminal and data communication server in the vehicle positioning monitoring system. Practice shows that the application of CORS service network and Mobile GIS in vehicle positioning monitoring system has improved the accuracy of spatial location of moving vehicles, and has helped visual display of located objects, which has also verified the feasibility to integrate CORS and Mobile GIS for mobile location services. It has important theoretical and practical value to further study the algorithm, model and technology of path analysis and map-matching in mobile location integrated with CORS and GIS.