It is shown that the two most important receptor systems of the brain are highly sensitive to the action of low-intensity electromagnetic radiation. Both the excitatory glutamatergic and inhibitory receptor system of gamma-aminobutyric acid react to the action of microwaves. Exposure to modulated microwaves with an intensity 50 μW/cm 2 and higher induces changes in the characteristics of binding of the receptors of gamma-aminobutyric acid of the A-type and glutamate receptors. To observe the effects, low-frequency modulation of microwaves is essential. Statistically significant changes in binding were observed at a modulation frequency of 16 Hz. The affinity of the ligands for the receptors of gamma-aminobutyric acid of type A and glutamate receptors changes in opposed manner: at the GABAergic synapses it decreases, and at the glutamatergic it increases. We assume that the effect of microwaves may be regarded as a stress factor for the organism.