Although PBL (problem-based learning) has gained increasing acceptance as an alternative to teacher-centered methods in nursing education, there are challenges to implementing this method in conventional course-based curriculums due to lack of additional faculty tutors to facilitate and monitor small group process. Little is known in nursing education regarding the effectiveness of teaching PBL in large group settings. [Woods, D. 1996. Problem-based Learning for Large Classes in Chemical Engineering. In: Wilkerson, L., Gijsaers, W. (Eds.), Bringing Problem-based Learning to Higher Education: Theory And Practice. Jossey-Bass, San Francisco, pp. 91–99] suggests that there are significant challenges related to student acceptance of the method, monitoring small group process and evaluating the quality of students’ work. This paper will provide a description of the process and outcome of using PBL in a second year Baccalaureate nursing course using both classroom and on-line learning technology. Findings from a student survey will be included to highlight the strengths and challenges of using PBL in a large group setting with one faculty tutor. Implications for using PBL in this format will be provided.