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We present the full NLO QCD corrections to the production of a W+W− pair in association with two jets in hadronic collisions, which is an important background to New Physics and Higgs boson searches. We include leptonic decays of the W-bosons with full spin correlations. We find NLO corrections of the order of 10% for standard cuts at the LHC. The scale dependence is considerably reduced by the NLO corrections.