Cerium oxide (CeO 2 ) was tested as a packing material in liquid chromatography for the separation of C 6 0 and C 7 0 fullerenes. The separation of C 6 0 and C 7 0 fullerenes could be achieved within 20 min by using puren -hexane as the mobile phase. Furthermore, some higher fullerenes could also be separated in less than 40 min. The peak area was reproducible to a large extent. The separation of fullerenes by liquid chromatography on CeO 2 is shown to be an effective method for their isolation in large amounts. The column efficiency of the CeO 2 column was compared with commercial silica gel and ODS columns. The main advantage of the CeO 2 column is its ability to separate large amounts of fullerenes (C 6 0 and C 7 0 ) in toluene.