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A hypothesis is postulated that high content of hydrogen donors and acceptors, and basic amino acids cause the intracellular trapping of the H+ and Cl− ions, which increases cancer risks as local formation of HCl is mutagenic to DNA. Other cations such as Ca2+, and weak acids such as short-chain organic acids may attenuate the intracellular gathering of the H+ and Cl−, two of the most abundant ions...
Hepatitis B virus is a major pathogen infecting the liver, causing high morbidity and mortality worldwide, particularly in developing countries. The mechanism underlying progression from infections of Hepatitis B virus to cirrhosis and liver cancer is not fully determined. Here we propose that the HBV X protein traps protons and Cl−, and induces the expression of collagen in the liver, which forms...
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