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Cylindromas are tumors which histogenesis apocrine or eccrine are discussed. It is a well known tumor, but not very frequent. Women are more affected than men (2:1). Appear at the early adulthood. Multiple lesions are dominantly inherited. 37% of single tumors become malignant. In multiple tumors malignancy increases to 63%. Some skin coloured papules, nodules or tumors progressing slowly in...
The author will analyse skin changes illustrated in several works of art and comment upon their meaning to the interpretation of the artist's and observer's way of living.
Demodex folliculitis and perioral dermatitis are typical imitators of rosacea. As folliculitis caused by Demodex folliculorum (demodicosis, demodicidosis, pityriasis folliculorum) is not recognized by some authors, the diagnosis is probably too rarely made. The appearance is discrete revealing inflammatory follicular papules or papulopustules on the cheeks, sometimes only on one side of the face,...
Twenty patients with seborrhoeic dermatitis of the scalp were treated with Lamisil (terbinafine) 1% solution once daily for 4 weeks. Patients were evaluated every 2 Weeks during treatment and after a 2 week follow up period. Evaluation included quantitative culture for Pityrosponan ovale, a clinical score of the severity of scalp lesions, and an overall evaluation for healing.All cleared patients...
Staphylococcus aureus is the chief human pathogen amongst the 30 or so species of staphylococci, though S. epidermidis and other skin residents are found in small pustules and other trivial lesions and they have a pathogenic role where plastic prostheses are used as in peritoneal dialysis. The spectrum of S. aureus skin disease is wide from colonization/infection of atopic dermatitis through impetigo...
Proliferation and death of cells are primary requirements for tissue homeostasis. They are carefully regulated in normal tissue. Increased cell proliferation or reduced cell death or a combination of both lead to tumor formation. An increased proliferation rate has long ago been recognized as a hallmark of malignancy. In addition to counting of mitotic figures, the more recent development of antibodies...
This lecture gives an overview of the classification of vasculitis syndromes relevant to the skin and focusses on the cutaneous, histological and systemic symptomatology of cutaneous necrotizing vasculitis, urticarial vasculitis, cutaneous polyarteritis nodosa, Wegener's granulomatosis and Churg Strauss granulomatosis. Differential diagnosis to livedoid vasculitis, Sneddon's syndrome and giant cell...
Khellin is used together with either UVA irradiation or sun exposure in the treatment of vitiligo. The patients may either be treated with khellin orally or topically. The major advantage of khellin compared with the psoralens is that it is not phototoxic, and thus can be considered safe for home treatment. In addition it has been considered rather harmless regarding carcinogenecity.However, in...
Aims. A prospective survey of the number and nature of cutaneous adverse drug reactions in a hospital setting.Methods. Six month survey of hospital in-patients. Patients assessed as having: i) expected side-effect (type A), ii) unexpected adverse reaction (type B), iii) not drug related, and iv) other.Results. Sixty patients were reviewed; 38 patients (63%) had a cutaneous adverse reaction. 7...
Reflectance spectroscopy is now commonly used to measure skin color, erythema, etc in the visible range. In UV. domain, mainly UV B range, technical problems remain. Commercially available devices quantify globaly the whole backscattered light using an integrating sphere.Skin is a diffusing medium and reflectance spectrum contains a variable part of regular reflected light. The ratio diffused light...
Superficial varicosities of the leg refer to dilatated venules. They mainly represent a cosmetical problem why many women are searching help for. The best established therapy is injection of sclerosating agents. In this way blue varicosities with a larger diameter can be removed but smaller telangiectatic varicosities often resist this therapy. Many side effects like ulceration of skin, hyperpigmentation,...
It is well known that climatic and heliometric characteristics of the Middle Europe and Central Asia are not similar particularly in the power of insolation. Following the result of clinical and epidemiologic investigation of 86 patients with epidermatropic lymphoma of the skin, living in Uzbekistan, where intensity and duration of solar radiation is 3-5 times as much the analogous indices in the...
In 1987, my group and I coined the acronym SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis Osteitis) syndrome to lump together dermato-rheunmtological conditions which so far have been described independently. It consists in a peculiar sterile osteitis, affecting mostly the anterior chest wall but also iliac bone, spine and even peripheral long bones. These involvements are frequently confused...
Tretinoin emollient cream 0.05% (TEC) has been shown in double-blind, vehicle-controlled studies to significantly improve photodamaged skin. The occurrence of skin irritation in TEC-treated patients raises the question of whether the blind was compromised and the clinical assessments influenced by the presence of irritation. Analyses comparing clinical response, based on investigator global evaluations...
There has always been a need for an adequate means of communication amongst specialists of all fields of medicine, and this has led to the proliferation of meetings and scientific journals throughout the world. The early roots of Dermatology involved distinguished continental schools in places like London, Paris and Vienna. The diversity of them and the visual aspect of the specialty made it logical...
This multicenter study was conducted to establish the optimal maintenance therapy in psoriatic patients after remission with ciclosporin.Cyclosporin (CYA) (mean 4.15 mg/kg/day) monotherapy was administered in 136 patients with PASI scores more than 20. One hundred six patients achieved remission (PASI score reduction rate more than 80%) and were randomly divided into 8 for following maintenance therapies:...
Eleven middle-aged male patients diagnosed clinically and confirmed pathologically as cutaneous leishmaniasis were treated with 200 mg itraconazole daily for one month. Nine cases showed complete cure with minimal scarring. One patient was resistant and needed a combination of itraconazole and intramuscular (sodium stibogluconate -- Pentostam). Another patient was improved only after intralesional...
The carbone dioxide laser (CO2 laser) has been used by dermatologists for more than 20 years, to treat various skin tumors.Technical improvements have widened its use to some aesthetic cases, such as those which could be treated with a peeling or a dermabrasion.We will compare CO2 laser and other more classic procedures, according to the disorder's nature and location.The CO2 laser, either used by...
Chemical peeling is a surgical procedure that refers to the use of one or more chemical agents for the destruction of the epidermis only or of the epidermis and part of the dermis, followed by healing with the replacement of the destroyed tissue. Chemical peeling is divided into light, medium depth and deep peeling based on cauterants used and skin depth of penetration. Chemical peeling is utilized...
A male infant is born with generalized erythroderma and scaling. The newborn demonstrates a persistent severe failure to thrive and develops several severe complications: episodes of hypernatremic deshydratation, septicemia; gastro-enteritis and seizures. In the neonatal period the crythema fades, but the exfoliation persists.The parents are healthy, but related (first cousins). One older brother...
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