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Background Future needs suggested by an international panel of dermatologists in April 1995 were listed as follows: (i) investigational trials to validate components of the existing treatment algorithms; (ii) continued support of research into the pathophysiology of allergic skin diseases; (iii) trials to test the efficacy and safety of new therapeutic approaches; and (iv) education of patients and...
Background Allergic skin disorders are initiated and maintained through the action and interaction between resident tissue cells, infiltrating leucocytes and mediators.Review The major cellular components of the skin immune system are keratinocytes, dendritic cells such as epidermal Langerhans cells (LCs) and dermal dendritic cells, mast cells and fibroblasts. Following an allergenic stimulus, inflammatory...
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