The follicular hyperkeratinization, that is an early event in acne, seems to be linked to a localized linoleate deficiency in the follicular epithelium, largely replaced by oleate production.The present study was conducted to determine whether the supposed overproduction of oleic acid, squalene and sebum, of an acne-affected skin could be influenced by topical applications of cosmetic emulsions containing as active ingredients an high concentration of esterified linoleic acid together with glycolic acid buffered by a special mixture of aminoacids.We controlled the Skin Hydration, TEWL, superficial skin lipids, level of linoleic acid and squalene (by 3C System, TLC and GC).From the obtained results it is clear that superficial skin lipids (-70%) and squalene concentration (-53%) decrease drastically, while linoleic acid concentration (+61%) increases. It was also noted an high reduction of all the inflammatory lesions (-75%), an increase of skin hydration (+82%) and a decrease of TEWL (-50%).Given the positive results obtained we believe that this special phospholipidic emulsion may be considered a new cosmeceutical and a useful aid for the acne therapy all year round.