This paper presents fatigue results for sandwich beams that exhibit a transition in failure mode, from core shear failure to face laminate tensile failure, as function of load amplitude only. The basis of this are fatigue tests of foam cores in shear and tensile tests on composite laminates. These results show that the slopes of the stress–life (S–N) relation are different for the core and laminates. By using the obtained stress–life relations, a simple design scheme is given for sandwich beams which are anticipated to have a transition of failure mode for a particular load level. Two designs are manufactured and tested in fatigue under constant amplitude loading. The results clearly show the aim of investigation with transitions in failure modes giving a structural stress–life diagram a bi-linear shape. For high load and small number of cycles to failure, the beams fail by core shear fracture while for lower loads, and large number of cycles to failure the beams fail by face sheet tensile failure.