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The increased use of recombinant cytokines and cytokine analogues in various disease therapies emphasizes the importance of antibodies to cytokines. Here, Klaus Bendtzen and colleagues discuss how immunological tolerance to cytokines may be broken, and the clinical relevance of cytokine autoantibodies. They also comment on the implications for refined passive immunization and cytokine vaccination...
Helicobacter pylori infection induces autoantibodies to gastric H + K + -ATPase similar to those found in autoimmune gastritis and pernicious anaemia (AIG/PA). Here, Ben Appelmelk and colleagues consider the possibility that H. pylori infection triggers an autoimmune process that leads to gastric atrophy and AIG/PA.
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