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Steroid hormones are widely known to influence expression of the hormone-responsive genes in target cells. The action of steroid hormones is known to be mediated by their initial binding to specific 'receptor' proteins. The exact sequence of events, which follow hormone binding and lead to a cellular response, has remained unclear. This timely meeting has provided a forum for discussion of the recent...
Estrogen receptor α (ERα)-negative breast cancer cells display an aggressive phenotype. We previously showed that adenoviral expression of ERα in ER-negative breast cancer cells leads to an estrogen-dependent down-regulation of the proliferation, which could be of interest to control the growth of such cells. In this study, we observed an increase in protein levels of p21 and p27 cyclin-dependent...
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