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The uptake of 125 I-labeled epidermal growth factor ( 125 I-EGF) by mouse pancreatic acini was inhibited (40-50%) by the secretagogue cholecystokinin octapeptide (CCK 8 ). Analysis of competitive binding data showed that the apparent K d of EEG binding increased 135% while the binding capacity was only slightly altered (30% increase). That the effect...
Enhancing factor (EF), a growth regulatory molecule, isolated from mouse small intestines, has been well characterized in this laboratory. It increases the binding of epidermal growth factor in a unique manner via its own receptor. In the first 20 N-terminal amino acids sequenced, EF showed 50% homology to human Group II phospholipase A2 (PLA2). Here we propose that EF is yet another, unidentified...
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