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The polyclonal anti-idiotypic antibody (Anti-Id) has been raised against a monoclonal antibody (mAb) that specifically binds to phosphatidylcholine (PC). The anti-Id bound strongly to PC-specific mAbs, but not to the other mAbs that bind to phosphatidylserine, indicating that the anti-Id recognizes the cross-reactive idiotopes expressed on the PC-specific mAbs. The anti-Id also showed an extensive...
Hybridomas producing monoclonal anti-idiotypic antibodies (anti-id MAbs) to N-acetylglucosaminyl-β1-4-N-acetylmuramyl-alanyl-d-isoglutamine (GMDP) were developed. Three clones of hybridomas demonstrated the properties characteristic for the Ab2β type of anti-id antibody: they bound to Fab-fragments of high-affinity MAb to GMDP; dose-dependent inhibition of this binding by GMDP was observed; immunization...
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