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The involvement of the small GTP-binding protein rab3A in synaptic transmission was tested by presynaptic microinjection of guanine nucleotides and peptides corresponding to the effector domain of rab3A. When GTPγS injection was paired with presynaptic action potentials, the frequency of MIPSCs was increased and the evoked synaptic current was reduced in magnitude. To more specifically manipulate...
The putative Rab3 effector RIM (Rab3-interacting molecule) was detected by Northern blotting, RT-PCR and Western blotting in native pancreatic β-cells as well as in the derived cell lines INS-1E and HIT-T15. RIM was localized on the plasma membrane of INS-1E cells and β-cells. An involvement of RIM in insulin exocytosis was indicated by transfection experiments of INS-1E cells with the Rab3 binding...
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