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The involvement of extracellular free Ca 2+ in histamine release was investigated in rat peritoneal mast cells. Incubation of non-antigenized cells in a media with high extracellular potassium did not increase histamine release. Secretion induced by A23187 and compound 4880 in the presence of Ca 2+ requires metabolic energy. In the absence of external free Ca 2+...
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