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Rv2027c is a putative orphan histidine sensor kinase that bears strong homology to DevS of the hypoxia-responsive DevR-DevS two-component system in M. tuberculosis. The cytosolic C-terminal domain of Rv2027c protein (Rv2027c 194 ) was overexpressed in E. coli and biochemically characterized. Rv2027c 194 underwent autophosphorylation at a conserved His 3 ...
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