The effect of the amount of magnesium aluminate spinel powder (MASP) in lightweight periclase-spinel refractories on the cement clinker corrosion and adherence properties was investigated by the static crucible test and sandwich test. The results showed that MASP addition significantly affected the cement clinker corrosion resistance and adherence properties although it had little effect on the apparent porosity and pore size of refractories. The spinel in the refractories reacted with the cement clinker rather than periclase to generate the glass phase. Its amount and viscosity increased from 0 to 13wt% MASP addition in refractories, which brought the benefit to the adherence strength. However, the excessive glass phase deteriorated the corrosion and penetration resistances of refractories as MASP was added up to 19wt%. So, the addition amount from 9 to 13wt% MASP into periclase-spinel refractories balanced the cement clinker resistance and adherence strength.