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Lipoid congenital adrenal hyperplasia (lipoid CAH) is a rare disorder of steroid biosynthesis that is caused by a molecular defect in the steroidogenic acute regulatory protein. Patients with lipoid CAH usually experience life-threatening adrenal insufficiency and develop female external genitalia in both genetic sexes because of deficient gonadal steroid synthesis. Little is known regarding testicular...
To identify the factors that might predict which individuals ultimately fail to resolve voiding symptoms by analyzing their presenting symptoms and video-urodynamic findings. Older children with intractable voiding dysfunction and no evidence of neurologic abnormality, who are recalcitrant to medical treatment, pose a management challenge.The charts of neurologically normal children with intractable...
To determine whether percutaneous nephrolithotomy (PCNL) can be safely performed in the high-risk patient.The records of 84 patients undergoing 98 consecutive PCNL procedures from January 2005 to January 2007 at a single institution were examined. Patients were divided into a high-risk preoperative group, which comprised patients having American Society of Anesthesiologist scores of III or IV (n =...
To identify the difference in autonomic nervous dysfunction activity in men between voiding symptom–predominant lower urinary tract symptoms (LUTS) and storage symptom–predominant LUTS.A total of 39 men with LUTS (mean age 56.9 ± 8.96 years) and 23 healthy men (mean age 57.0 ± 1.76 years) were included in the present study. Seven questions numbered Q1 to Q7 in the order of appearance in International...
To perform a population-based analysis of the potential staging or prognostic value (or both) of lymph node dissection (LND) in patients without nodal metastases vs no LND. In several previous reports, LND in patients with upper tract urothelial carcinoma (UTUC) treated with nephroureterectomy (NU) was associated with better survival relative to no LND (pN x ), even in the absence of pathologically...
To assess the efficacy and the simplicity of a modified open transvesical prostatectomy for large prostates (>80 mL).A total of 165 patients with benign prostatic hyperplasia were treated with transvesical prostatectomy through a 3-cm incision. Prostate size was 85-144 cm 3 (mean 101 cm 3 ). Surgery is performed as the standard transvesical prostatectomy but skin incision is much...
To describe laparoendoscopic single site (LESS) donor nephrectomy procedure through a Pfannenstiel incision. Laparoscopic donor nephrectomy has become the standard approach in harvesting kidneys from live donors. This is usually performed through 3 ports placed in a triangular manner in addition to the Pfannenstiel incision where the kidney is removed.Through a 5 cm Pfannenstiel incision, three 5...
To investigate the relationship between the severity of urine leakage and quality of life (QOL) in men and women of different race/ethnicity.An epidemiologic survey was conducted with a population-based random sample of 3202 women and 2301 men (1767 black, 1877 Hispanic, 1859 white) aged 30-79 years in Boston, MA. Severity of leakage was based on frequency and amount by the Sandvik Severity Scale...
To further explore the phenomenon of minimal bleeding after histotripsy by performing extensive prostate histotripsy treatments in anticoagulated canines. Histotripsy is a noninvasive ultrasound technology which induces microbubble formation (cavitation) within tissues producing mechanical tissue fractionation. During initial in vivo feasibility canine studies of prostate ablation, minimal hematuria...
To examine the treatment outcomes of men who would have been eligible for active surveillance (AS) but underwent immediate radical retropubic prostatectomy (RRP). AS protocols are designed to spare the potential morbidity of treatment to patients with low-risk prostate cancer (PCa).From a prospective RRP database, we evaluated the tumor features and treatment outcomes for men who would have met 1...
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