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To examine the reflux nephropathy rate and severity as well as the hypertension rate in pediatric patients with vesicoureteral reflux (VUR).The study included 240 patients with VUR. Renal scarring (RS) was demonstrated by renal parenchymal examination using technetium-99m–labeled dimercaptosuccinic acid ( 99m Tc-DMSA) scintigraphy. Office measurements of arterial blood pressure and ambulatory...
Endoscopic correction of vesicoureteral reflux using dextranomer/hyaluronic acid copolymer (Deflux) is a widely used technique. Complications are uncommon, and ureteral obstruction occurs particularly infrequently. We present a case of delayed symptomatic partial bilateral ureteral obstruction after bilateral high-volume (>1.0mL) Deflux injections that required surgical repair 16months after injection...
To determine whether an association exists between interstitial cystitis/bladder pain syndrome (IC/BPS) and a nonsynonymous single nucleotide polymorphism in the SCN9A voltage-gated sodium channel gene previously associated with other chronic pain syndromes.Germline deoxyribonucleic acid was sampled from archived bladder biopsy specimens from patients with a documented diagnosis of IC/BPS. Deoxyribonucleic...
Crossed ectopia is a rare congenital anomaly. S-shaped (sigmoid) kidney is one of the varieties of crossed ectopia that is associated with absence of any renal tissue in the contralateral renal fossa. S-shaped malformation of an ipsilateral kidney with presence of the contralateral kidney is an extremely rare condition and, to our knowledge, has been described only once before in the literature. We...
To assess the ability of daily oral simvastatin administration to reduce the negative urodynamic changes associated with cyclophosphamide (CP)-induced cystitis and to prevent bladder inflammation. Patients undergoing CP chemotherapy frequently develop cystitis, leading to urinary dysfunction and hemorrhage. Recent studies have suggested statins possess anti-inflammatory properties and might be uroprotective...
To compare the ergonomics and workload of the surgeon during single-site suturing while using the magnetic anchoring and guidance system (MAGS) camera vs a conventional laparoscope.Seven urologic surgeons were enrolled and divided into an expert group (n = 2) and a novice group (n = 5) according to their laparoendoscopic single-site (LESS) experience. Each surgeon performed 2 conventional LESS and...
To review the merit of the U.S. Food and Drug Administration-issued warnings on the use of transvaginal mesh in women with pelvic organ prolapse because of escalating complications.On institutional review board approval, we reviewed the data from 2 tertiary institutions managing complications of transvaginal mesh. The data recorded included mesh type, details of surgical removal, and patient-reported...
Self-inserted foreign bodies in the lower urinary tract are rare among children. The treatment of foreign bodies in the urethra is determined by their type, size, location, shape, and mobility. We describe here a 13-year-old boy who had self-inserted a needle into his urethra out of curiosity. Initial attempts to remove the needle from the urethra by inserting a cystoscope failed due to the weak biting...
To determine the effect of tamsulosin hydrochloride on blood flow in the submucosal capillaries of the bladder (SCB) in a rat model of bladder outlet obstruction (BOO) using a pencil lens charge-coupled device microscopy system.BOO was established in rats by partial ligature of the proximal urethra and was maintained for 2 weeks. Tamsulosin or saline (control) was subcutaneously administered using...
To establish whether the activities of Na + /K + -adenosine triphosphatase (ATPase) and Ca 2+ -ATPases ion pumps in bladder smooth muscle are altered as a consequence of diabetes and, if so, how this might contribute to bladder cystopathy. Urinary bladder dysfunction is a common occurrence in patients with diabetes. Pressure generation requires calcium and cytosolic ATP. Activities...
To compare the results of retroperitoneal laparoscopic adrenalectomy using the antegrade and retrograde approach.We performed an analysis of a single-center series of 279 retroperitoneal laparoscopic adrenalectomies from 1996 to 2010. We compared 172 cases performed with an antegrade approach and 107 with a retrograde approach without dissection of the renal hilum and initial control of the adrenal...
To investigate the expression of c-Jun N-terminal kinase (JNK) 1/2 in human hypospadiac tissue compared with that in normal penile tissue.Penile skin tissue specimens obtained at surgery during hypospadias repair or during elective circumcision were divided into 3 groups according to the position of the urethral meatus: children with mild hypospadias (n = 16), severe hypospadias (n = 16), and normal...
To assess the current etiology, features, and natural history of urethral stricture disease in the developed world.We analyzed the data from 1439 male patients with urethral stricture, who had undergone surgical treatment in our referral urethral center from 2000 to 2010. The preoperative evaluation included a detailed clinical history of stricture, uroflowmetry, retrograde and voiding cystourethrography,...
To investigate whether the normal expression of metastasis-associated protein 1 (MTA1) in Sertoli cells (SCs) is associated with adjacent germ cells (GCs) and to provide the functional relevance of MTA1 in this somatic cell.The expression pattern of MTA1 in the SCs of impaired human spermatogenesis was determined using immunohistochemistry. The effect of the depletion of GCs on the expression of MTA1...
A 68-year-old woman was diagnosed to have a left-to-right L-shaped crossed-fused kidney with staghorn calculi in both renal moieties on evaluation for abdominal pain. She underwent supine percutaneous nephrolithotomy using 3 tracts in 3 stages. By using 3-dimensional reconstructed computed tomography urogram, proper preoperative planning, appropriate patient positioning, ultrasound-guided access,...
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