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Synthesis, evaluation and Tc-99m complexation of a hydrazinonicotinyl conjugate of a gp IIb/IIIa antagonist cyclic peptide for the detection of deep vein thrombosis
A cyclic peptide GP IIb/IIIa receptor antagonist containing the N-Me-Arg-Gly-Asp motif has been derivatized with the technetium chelating hydrazinonicotinyl group (Hynic). The Hynic derivative, and the Tc-99 diazenido complex, retain the high receptor affinity of the parent peptide. The Tc-99m complex shows high thrombus uptake, and rapid clearance of background, producing excellent images in under 1 h.