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Mitoxantrone (MH 2 X), an anthraquinone-type anti-cancer agent used clinically in the treatment of human malignancies, is oxidatively activated by the peroxidase/H 2 O 2 enzyme system. In contrast to the enzymatic mechanisms of drug oxidation, the chemical transformations of MH 2 X are not well described. In this study, MH 2 X metabolites, produced by the horseradish,...
Steroid Receptor RNA Activator (SRA) occupies a unique and enigmatic position within the nuclear receptor (NR) field and more broadly in transcriptional regulation. This is as a result of its transcripts having both coding and non-coding coactivator activities along with its protein product SRAP performing mixed coactivator/repressor functions. Recent publications have provided greater understanding...
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