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(−)-epigallocatechin-3-gallate (EGCG) has been shown to possess chemopreventative properties and the ability to inhibit proteasome, a multicatalytic protease involved in the removal of oxidized and misfolded proteins and in the turnover of important checkpoint proteins. The stability of EGCG under neutral-alkaline and cellular physiological conditions was evaluated, identifying a biologically active...
(−)-Epigallocatechin-3-gallate (EGCG), a well-known chemopreventive factor, induces cancer cells undergoing apoptosis. Over the last several years, we have shown that the mitochondrial NADP + -dependent isocitrate dehydrogenase (IDPm) functions as an antioxidant and anti-apoptotic protein by supplying NADPH to antioxidant systems. Here, we show that EGCG induced the inactivation of IDPm as...
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