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Using a gene trap approach in ES cells, the novel mouse gene Trm1-like with substantial sequence homology to human C1orf25 mRNA (GenBank accession no. AF288399) was identified. Murine Trm1-like encodes a putative protein with limited similarity to N2,N2-dimethylguanosine tRNA methyltransferase (Trm1) from other organisms, however its function is not known. The potential role of Trm1-like was investigated...
Whole genome sequence data permit the study of protein families regulating cellular homeostasis during development. Here we present a study of the sea urchin Ca 2+ -ATPases made possible by the Sea Urchin Genome Sequencing Project. This is of potential interest because adult sea urchins, their gametes and embryos live in the relatively high Ca 2+ concentration of 10 mM. Three Ca ...
In P. lividus sea urchin the H3.3 histone variant is coded by an mRNA characterized by a long 3′UTR containing ARE (AU-Rich element) motifs. RNA stability assays performed in rabbit reticulocyte lysate showed that such 3′UTR affects the degradation rate of the transcripts. In fact, chimeric molecules containing the 3′UTR of H3.3 transcript, ligated to the coding region of the rabbit β-globin transcript,...
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