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To determine both the negative and positive predictive values of comprehensive chromosome screening (CCS) results for clinical outcome.Data obtained from two prospective, double-blinded, nonselection studies.Academic center for reproductive medicine.One hundred forty-six couples with a mean maternal age of 34.0 ± 4.4 years and a mean paternal age of 37.3 ± 5.8 years.Embryo biopsy for DNA fingerprinting...
To develop and validate a quantitative real-time polymerase chain reaction (qPCR)–based method for blastocyst trophectoderm comprehensive chromosome screening (CCS) of aneuploidy.Prospective, randomized, and blinded.Academic center for reproductive medicine.Nine cell lines were obtained from a commercial cell line repository, and 71 discarded human blastocysts were obtained from 24 IVF patients that...
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