The surface characteristics of an implant that influence the speed and strength of osseointegration include crystal structure and bioactivity. The aim of this study was to evaluate the bioactivity of a novel natural hydroxyapatite/zircon (NHA/zircon) nanobiocomposite coating on 316L stainless steel (SS) dental implants soaking in simulated body fluid. A novel NHA/zircon nanobiocomposite was fabricated with 0 (control), 5, 10, and 15wt% of zircon in NHA using ball mill for 1h. The composite mixture was coated on SS implants using a plasma spray method. Scanning electron microscopy (SEM) was used to evaluate surface morphology, and X-ray diffraction (XRD) was used to analyze phase composition and crystallinity (X c ). Further, calcium ion release was measured to evaluate the coated nanobiocomposite samples. The prepared NHA/zircon coating had a nanoscale morphological structure with a mean crystallite size of 30–40nm in diameter and a bone-like composition, which is similar to that of the biological apatite of a bone. For the prepared NHA powder, high bioactivity was observed owing to the formation of apatite crystals on its surface. Both minimum crystallinity (X c =41.1%) and maximum bioactivity occurred in the sample containing 10wt% of zircon because of minimum X c and maximum biodegradation of the coating sample.