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The value of adjuvant chemotherapy for some patients with stage III colorectal cancer has been established but the situation is less clear for stage II disease. Currently, infusional or bolus 5-fluorouracil (5-FU)/folinic acid (FA) is the treatment of choice but its success is limited and the use of combination therapies is now being investigated. The efficacy of irinotecan in metastatic disease has...
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