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A platinum-taxane doublet has been established as the standard of care in the initial chemotherapy for ovarian cancer. Treatment at relapse is based largely on the platinum-free interval (PFI). Women with a PFI of 6–12 months are said to be partially platinum-sensitive. Based on the evidence from randomised trials, many clinicians offer treatment to this group with a platinum-containing doublet (including...
A significant advance in cancer treatment was achieved in the mid-1990s with the introduction of solvent-based taxanes. However, first-generation taxanes required synthetic solvents to promote parenteral administration, occasionally caused serious toxicities, and compromised treatment efficacy. This led to the development of second-generation taxanes, including a solvent-free albumin-bound form of...
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