Gargano is a small mountainous promontory protruding into the Southern Adriatic and, from a structural point of view, it is part of the Apulia foreland. Deformative structures, both inland and offshore the promontory, are quite common and can partially be associated with a substantial Quaternary uplifting. Seismogenically this area is well known, because several historical strong earthquakes have been reported to occur here and recent important seismic sequences have been recorded. This paper is a contribution to evaluate the seismogenic as well as the tsunamigenic potential of this region. Particular attention has been given to study the major events, some of which were able to produce tsunamis. The epicenter location of some of these earthquakes computed solely on the basis of macroseismic data would point to focal regions on land, but this is questionable if tsunami generation is taken into account. As regards the tsunamigenic potential, statistical analysis is used to evaluate the local geographical distribution of expected tsunamis and the mean return periods. It is found that large events are expected on average every 228 years, while a tsunami of any size is generated every about 84 years, which is in good agreement with the experimental observations.