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An expedient synthesis of ortho-methoxy substituted 9-keto-5-phenylmorphans has been developed, featuring a Thorpe-Zieger cyclization to construct the substituted 2-phenylcyclohexanone intermediate.
Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthBethesda, Maryland 20892-0815United States of America
Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthBethesda, Maryland 20892-0815United States of America