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O 6 -methylguanine-DNA methyltransferase (MGMT) plays a crucial role in the defense against alkylating agents that generate, among other lesions, O 6 -alkylguanine in DNA (collectively termed O 6 -alkylating agents [O 6 AA]). The defense is highly important, since O 6 AA are common environmental carcinogens, are formed endogenously during normal cellular metabolism...
The DNA repair protein O 6 -methylguanine-DNA methyltransferase (MGMT) is a cardinal defense against the mutagenic and carcinogenic effects of alkylating agents. We have reported evidence that absence of detectable MGMT activity (MGMT − phenotype) in human brain is a predisposing factor for primary brain tumors that affects ca. 12% of individuals [J.R. Silber, A. Blank, M.S. Bobola,...
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