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Recent elucidation of the structure of interleukin-1β-converting enzyme (ICE), a protease with sequence homology to a nematode protein associated with programmed cell death, opens a new chapter in the study of how proteases may control cellular suicide.
Carlo M Nalin, Department of Oncology, Preclinical Research, Sandoz Research Institute, Sandoz Pharmaceuticals Corporation, East Hanover, NJ 07496, USA