The effects of 12-weeks of HMB ingestion and resistance training (RT) on abdominal adiposity were examined in 48 men (66–78yrs). All participants were randomly assigned to 1 of 4 groups: no-training placebo (NT-PL), HMB only (NT-HMB), RT with PL (RT-PL), or HMB with RT (RT-HMB). DXA was used to estimate abdominal fat mass (AFM) by placing the region of interest over the L1–L4 region of the spine. Outcomes were assessed by ANCOVA, with Bonferroni-corrected pairwise comparisons. Baseline AFM values were used as the covariate. The ANCOVA indicated a significant difference (p=0.013) between group means for the adjusted posttest AFM values (mean (kg)±SE: NT-PL=2.59±0.06; NT-HMB=2.59±0.61; RT-PL=2.59±0.62; RT-HMB=2.34±0.61). The pairwise comparisons indicated that AFM following the intervention period in the RT-HMB group was significantly less than NT-PL (p=0.013), NT-HMB (p=0.011), and RT-PL (p=0.010). These data suggested that HMB in combination with 12weeks of RT decreased AFM in elderly men.