During the last few years, in continuing program to discover antipsychotic and anxiolytic agents we have synthesized in our Department a series of N-substituted cyclic imides and diimides. The highest pharmacological activity - affinity to 5-HT 1 A serotonine receptors and activity in behavioral tests - display compounds related to bicyclo[2.2.2]oct-7-ene and bicyclo[2.2.2]octane.Continuing our research we have synthesized now a new derivatives of bicyclo[2.2.2]oct-2-ene. Initial compounds for two series; 1,4-diacetoxybicyclo[2.2.2]oct-2-ene-5,6-dicarboximide (1) and 3-acetoxy-1-methoxybicyclo[2.2.2]oct-2-ene-5,6-dicarboximide (2) were synthesized in Diels-Alder reaction [1]. Imides 1 and 2 were condensed with 1-bromo-4-chlorobutane and then - with appropriate arylpiperazine.