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We report an audit of skin cancers reported by pathologists across the North of England Cancer Network.We examined 386 reports to determine whether core data items recommended by the National Minimum dataset had been included in the pathology reports.Only 115 of the 386 reports (30%) had all the expected data items compared to the expected standard of 90%. Melanoma reports were more often fully compliant...
Liquid biopsy has the potential to provide information about cancers without invasive biopsy, using circulating biomarkers. These include proteins, RNA and DNA. They can be used in detection, diagnosis, monitoring and detection of recurrence. While protein-based tumour markers have been used in routine pathology for many years, the ability to detect mutations in circulating DNA is relatively new,...
Next-generation sequencing (NGS) technologies have begun to revolutionize the field of haematological malignancies through the assessment of a patient's genetic makeup with a minimal cost. Significant discoveries have already provided a unique insight into disease initiation, risk stratification and therapeutic intervention. Sequencing analysis will likely form part of the routine diagnostic testing...
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