A 35-yr-old Canadian experienced burning and swelling of his throat with difficulty swallowing following his first ingestion of Lactaid tablets, a lactase supplement intended for the treatment of lactose intolerance. He gave positive reactions in skin prick tests with the Lactaid tablets, and to the enzyme (lactase from Aspergillus oryzae) they contained. The cause of his sensitization was possibly a previous ingestion of a Lacteeze brand of milk, a milk that contains lactase fromSaccharomyces fragilis . He responded to this brand in skin prick tests (but not to a Lactaid milk brand which contains lactase derived from Kluyveromyces lactis). The investigator claimed this to be the first report of allergic reaction to ingested Aspergillus-derived lactase.
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