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The diagnosis of hereditary cancer syndromes is basing mainly on pedigree analysis and if possible on molecular studies. We present 2 families which were diagnosed with hereditary cancer syndromes. Family I - breast cancer syndrome; 9 breast cancer cases were diagnosed in women between 25 and 45-year-of-age from 4 generations. The BRCA1 5382insC mutation was found in family members. Family II - hereditary...
The article reports a case of pathological fracture of the left humerus which occurred on the second postoperative day after a right-side modified radical mastectomy in patient primary diagnosed with an early stage of breast cancer. Lack of any clinical symptoms of bone metastasis were observed before surgery. The patient received operative treatment, i.e. resection of diaphyseal lesion and stabilization...
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