This essay include in two principal parts. The first part contains my Python programming tutorial notes and exercises regard to the course of “Information System” by professor Demartini (Politecnico di Torino). In addition, second part comprises my Quiz notes deals with the first 9 chapters of the considered textbook “Introduction to Information System” by James A. O’Brien and George M. Marakas, sixteenth edition. I feel responsible for clarifying that “My Information System Notes” is exclusively my personal and not official note. Those are my individual notes and my own understanding with margin probability of errors and misunderstanding. Therefore, I invite all readers to progress their individual research in parallel. In another hand, my own interesting story which encouraged me to prepare these notes and monolith them all together in a unique e-note format, return to my history in Italy and my orientation with Marakas&O’brien's book in 2014, when I used to work in an Italian family-run international transport company in Nord and I worked many hours per day, far away from my family.