Role of Tosyl Cellulose Acetate as Potential Carrier for Controlled Drug Release

Cellulose is a naturally occurring organic polymer. The chemical functionalization of cellulose is conducted to adjust its properties for different purposes. In the present study, cellulose was extracted from bagasse, derivatized to acetate, and chemically modified again to prepare tosylated cellulose acetate. The prepared cellulose derivatives were investigated by Fourier transform infrared spectroscopy and scanning electron microscopy. Tosyl cellulose acetate was evaluated as a potential carrier for the controlled release of pH-sensitive drugs. The release was investigated as a function of pH and time at various pH values. The results find their use in controlled release applications.