Cardiovascular disease is one of the main causes of mortality and morbidity in diabetic patients. This study evaluated the effects of diabetes on myocardial capillary density and several serum angiogenic factors including nitric oxide, vascular endothelial growth factor, and soluble vascular endothelial growth factor receptors. Nitric oxide (NO) and vascular endothelial growth factor (VEGF) are important factors affecting angiogenesis.NO has important roles in multiple physiological processes and pathological states, and VEGF and its receptors have essential roles in pathological and physiological angiogenesis. The two VEGF receptor subtypes that are primarily involved in angiogenesis are VEGF receptor type 1 (VEGFR-1) and VEGF receptor type 2 (VEGFR-2). Soluble VEGFR-1 (sVEGFR-1) binds with a high affinity to VEGF and reduces VEGF activity and angiogenesis, whereas VEGFR-2 has proangiogenic effect in the angiogenesis process.Increased VEGF-mediated angiogenesis in diabetic retinopathy and nephropathy and a decreased angiogenic response in wound healing and ulcers have been documented in diabetic subjects.
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Erekat NS, Al-Jarrah MD, Al Khatib AJ. Treadmill exercise training improves vascular endothelial growth factor expression in the cardiac muscle of type I diabetic rats. Cardiology research. 2014 Feb;5(1):23.
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