Cell death is the hallmark of many neurological diseases, the processes underlying this death are still poorly defined. Neuronal cell death predominantly proceeds by regulated processes. Cell death pathway include apoptosis, autophagy and necrosis.
Erekat NS. Apoptotic mediators are upregulated in the skeletal muscle of chronic/progressive mouse model of Parkinson's disease. The Anatomical Record. 2015 Aug;298(8):1472-8.
Pfeiffer A., Schneider J., Bueno D., Dolga A., Voss T. D., Lewerenz J., et al. . (2017). Bcl-xL knockout attenuates mitochondrial respiration and causes oxidative stress that is compensated by pentose phosphate pathway activity. Free Radic. Biol. Med. 112, 350–359. 10.1016/j.freeradbiomed.2017.08.007
Erekat NS. Autophagy precedes apoptosis among at risk cerebellar Purkinje cells in the shaker mutant rat: an ultrastructural study. Ultrastructural pathology. 2018 Mar 4;42(2):162-9.
Financed by the National Centre for Research and Development under grant No. SP/I/1/77065/10 by the strategic scientific research and experimental development program:
SYNAT - “Interdisciplinary System for Interactive Scientific and Scientific-Technical Information”.