CNS>Molecular Pathology of Neurodegenerative Disease>12-28
Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons. Many neurodegenerative diseases – including amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, and Huntington's disease – occur as a result of neurodegenerative processes. Such diseases are incurable, resulting in progressive degeneration and/or death of neuron cells. As research progresses, many similarities appear that relate these diseases to one another on a sub-cellular level. Discovering these similarities offers hope for therapeutic advances that could ameliorate many diseases simultaneously. There are many parallels between different neurodegenerative disorders including atypical protein assemblies as well as induced cell death. Neurodegeneration can be found in many different levels of neuronal circuitry ranging from molecular to systemic as a result of ROS.
Erekat NS. Cerebellar Upregulation of Cell Surface Death Receptor–Mediated Apoptotic Factors in Harmaline-Induced Tremor: An Immunohistochemistry Study. Journal of Cell Death. 2018 Nov;11:1179066018809091.
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