To adjust the properties of the macromolecular structure of cellulose, chemical modification can take place to find different applications. In the current study, cellulose was extracted from bagasse, where it was derivatized to carboxymethyl cellulose, and carbanilated cellulose. These two cellulose derivatives were further chemically modified in homogenous system by tosyl and trimethylsilylation to synthesize cellulose macromolecular derivatives, namely tosylcellulose derivatives and trimethylsilylcellulose derivatives. The compositional microstructure of the synthesized cellulose derivatives was investigated by 1 HNMR analysis, FT-IR and SEM. This study demonstrated that cellulose, cellulose derivatives and both tosyl and trimethylsilyl cellulose derivatives formed under homogeneous conditions can be evaluated as potential carriers for controlled release of anti-acid drugs. The release was investigated as a function of pH and time in various pH solutions, namely 2.0, 3.5 and 5.0. The results indicated that the release is controlled by the type of the modified cellulose and thus it was concluded that modification is important for the use in slow drug release.
Financed by the National Centre for Research and Development under grant No. SP/I/1/77065/10 by the strategic scientific research and experimental development program:
SYNAT - “Interdisciplinary System for Interactive Scientific and Scientific-Technical Information”.