Resorcinol is widely used in manufacturing of several drugs and pharmaceutical products that are mainly used for topical ailments. The main objective of this study is to use an alternative strategy i.e., biofield treatment to alter the physical, spectral and thermal properties of resorcinol. The resorcinol sample was divided in two groups, which served as control and treated group. The treated group was given biofield treatment and both groups i.e., control and treated were analysed using X-ray diffraction (XRD), Fourier transform-infrared (FT-IR) spectroscopy, UV-Visible (UV-Vis) spectroscopy, Differential scanning calorimetry (DSC) and Thermogravimetric analysis (TGA). The results showed a significant decrease in crystallite size of treated sample i.e., 104.7 nm as compared to control (139.6 nm). The FT-IR and UV-Vis spectra of treated sample did not show any change with respect to control. Besides, thermal analysis data showed 42% decrease in latent heat of fusion. The onset temperature of volatilization and temperature at which maximum volatilization happened was also decreased by 16% and 12.86%, respectively. The significant decrease in crystallite size may help to improve the spreadability and hence bioavailability of resorcinol in topical formulations. Also increase in volatilization temperature might increase the rate of reaction of resorcinol when used as intermediate. Hence, biofield treatment may alter the physical and thermal properties of resorcinol and make it more suitable for use in pharmaceutical industry.