Small and medium enterprises (SME) are faced with the need for a strategic response to the changes in global business environment. The aim of the article is to present the basic attributes of new businesses model determining success of SMEs in the new world of globalization. In the first part of article the impact of globalization on businesses sector is presented. In second part of this paper we discuss the future of SME in new world of global economics. Presented are changes in character and functioning of the small and medium enterprises. Special attention is devoted to three crucial attributes of new businesses model which will determine future success of small and medium enterprises in new world of global economics: a) implementation of new businesses types in SMEs sector, b) implementation of innovation, information and communication technologies by SMEs, c) implementation of strategic management by SMEs.