A 23factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), binder concentration (c) and relative density of tablet (d) on the disintegration time (DT) and dissolution times,t1,t50andt90, of paracetamol tablet formulations. The factorial design was also used to study the quantitative effects of pregelatinization of starch binders on these parameters,i.e., N,candd.In general, the most common ranking of the individual effects onDT,t1,t50andt90for native/native, pregelatinized/pregelatinized and native/pregelatinized starch binder formulations wasc>d> N. For interaction effects, the most common ranking was N-c>c-d> N-dfor all formulations. The results generally showed thatccan considerably affectDT, t1,t50andt90of the tablets
