Some 4-aryl-5,6-dihydro-6-(substituted phenyl)-4H-1,3-oxazine- 2-amine derivatives including 4-(4-methyl-1-naphthyl)-5,6- dihydro-6-(substituted phenyl)-4H-1,3-oxazine-2-amines have been synthesised by hydroxyapatite catalyzed solvent-free cyclization of aryl chalcones and urea using microwave irradiation under solventfree condition. The yields of the oxazines were more than 85%. The synthesised oxazine amines have been characterized by their physical constants, analytical and spectroscopic data.
 J. Cherian, I. Choi, A. Nayyar, U.H. Manjunatha, T. Mukherjee, Y.S. Lee, H.I. Boshoff, R. Singh,Y. H. Ha, M. Goodwin, S.B. Lakshminarayana, P. Niyomrattanakit, J. Jiricek, R. Ravindran, T. Dick, T.H. Keller, V. Dartois, C.E. Barry, J. Med. Chem., 54(16), 5639 (2011).
 A.M. Thompson, H.S. Sutherl , D.B. Palmer, I. Kmentova, A. Blaser, S.G. Franzblau, B. Wan, Y. Wang, Z. Ma, W.A. Denny, J. Med. Chem., 54(16), 6563, (2011).
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