Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and thin-layer chromatography (TLC) have been used to study dopamine and iron mediated free-radical transformation of lipids in their hydrophilic parts. It has been shown that the action of the dopamine/Fe2+ system on galactocerebroside or cardiolipin, which are the components of mixed micelles, results in formation of ceramide or phosphatidic acid and phosphatidylhydroxyacetone, respectively. These data, when combined with results obtained using the ascorbate/Fe2+/H2O2 oxidizing system with the same substrates, demonstrate that the formation of these products proceeds via an OH-radical induced fragmentation taking place in polar moiety of the starting lipids. <alternatives> [...] </alternatives>
 D.G. Graham, S.M. Tiffany, W.R. Bell Jr. and W.F. Gutknecht: ”Autoxidation versus covalent binding of quinones as the mechanisms of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C 1300 neuroblastoma cells invitro”, Mol. Pharmacol., Vol. 14, (1978), pp. 644–653.
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