Synthesis of the first phosphorus (V) porphyrin-peptide conjugate was successfully accomplished. A biologically active peptide, leucine enkephalin, was constructed on the phosphorus atom of the 5,10,15,20-meso-tetraphenylporphinato dichlorophosphorus (V) chloride. The method involved solution phase peptide synthesis. The first C-terminal amino acid in the sequence of the peptide was axially attached to the porphyrin through a linker, 3-aminopropanol, and the remainder of leucine enkephalin was synthesized by subsequent additions of amino acids. Leucine enkephalin-P(V) porphyrin conjugate represents a new group of compounds, and its synthesis broadens potential applications of P(V) porphyrine, e.g. in photodynamic therapy.
 H. Li and L. Czuchajowski: “Synthesis and biomedical application of porphyrinyl nucleosides, nucleotides and oligonucleotides”, Trends in Heterocyclic Chemistry, Vol. 6, (1999), pp. 57–77, and the references therein.
 X. Wang, O.S. Fedorova, W.R. Trumble and L. Czuchajowski: “Porphyrin-psoralen conjugate as a new DNA ligand”, Russian Journal of Bioorganic Chemistry, Vol. 25, No. 3, (1999), pp. 220–225.
Financed by the National Centre for Research and Development under grant No. SP/I/1/77065/10 by the strategic scientific research and experimental development program:
SYNAT - “Interdisciplinary System for Interactive Scientific and Scientific-Technical Information”.