Molecularly imprinted polymers (MIPs) are synthetic receptors with tailor-made recognition sites for the target molecules. Their high molecular recognition ability, good stability, easy preparation, and low cost make them highly promising substitutes for biological receptors. Recent years have witnessed rapidly increasing interest in the imprinting of biomacromolecules and especially proteins because of the great potential of these MIPs in such applications as proteome analysis, clinical diagnostics, and biomedicine. So far, some useful strategies have been developed for the imprinting of proteins and controlled radical polymerization techniques have proven highly versatile for such purpose. This mini-review describes recent developments in the controlled preparation of proteins-imprinted polymers via such advanced polymerization techniques.
Key Laboratory of Functional
Polymer Materials (Ministry of Education), State Key Laboratory
of Medicinal Chemical Biology, Collaborative Innovation Center
of Chemical Science and Engineering (Tianjin), and College of
Chemistry, Nankai University, Tianjin 300071, P. R. China
Financed by the National Centre for Research and Development under grant No. SP/I/1/77065/10 by the strategic scientific research and experimental development program:
SYNAT - “Interdisciplinary System for Interactive Scientific and Scientific-Technical Information”.